Comments on: Obesity, With or Without Insulin Resistance? http://www.robbwolf.com/2007/10/30/obesity-with-or-without-insulin-resistance/ The Paleo Solution book and podcast | Paleo diet, Paleolithic nutrition, intermittent fasting, and fitness Wed, 08 Feb 2012 20:24:43 +0000 hourly 1 http://wordpress.org/?v=3.3.1 By: Murdering Metabolism: A Crime Against Your Body | Acai Berry Life Cleanse http://www.robbwolf.com/2007/10/30/obesity-with-or-without-insulin-resistance/#comment-1172 Murdering Metabolism: A Crime Against Your Body | Acai Berry Life Cleanse Wed, 05 May 2010 07:45:30 +0000 http://robbwolf.com/?p=37#comment-1172 [...] Obesity, With or Without Insulin Resistance? – I wanted to thank Ratzo for a great question and also for tracking down a citation for further discussion. Here is the original question: Hi Robb,I posted this question on Art Devany’s site, since I am very curious about it. … [...] [...] Obesity, With or Without Insulin Resistance? – I wanted to thank Ratzo for a great question and also for tracking down a citation for further discussion. Here is the original question: Hi Robb,I posted this question on Art Devany’s site, since I am very curious about it. … [...]

]]> By: Ed Calabrese http://www.robbwolf.com/2007/10/30/obesity-with-or-without-insulin-resistance/#comment-1171 Ed Calabrese Sat, 15 Dec 2007 13:24:41 +0000 http://robbwolf.com/?p=37#comment-1171 Dear Robb: I just saw the listing of your article on hormesis and look forward to receiving it in the very near future. As you may know, I have been researching this area for a long time. I have come to believe that hormesis will define the performance capacity of all biological systems. If you would like me to send you pdfs of my published articles on hormesis I would be pleased to do so. Ed Calabrese Ed- I am absolutely familiar with your work and I'd love anything you might have the time to send. robb at norcalsc dot com Hormesis and punctuated equilibrium are truly fascinating topics. Coach Greg Glassman has put forward the notion that crossfit is effective as a strength & conditioning program because (in his words) crossfit "Increases work capacity across broad time and modal domains". To me this is almost an operational definition of life AND is illustrative of the need for punctuated, intense stimuli. Hormesis also explains the seeming contradiction between oxidative stress and the inability of antioxidant supplementation to improve/ameliorate disease states. really interesting stuff! Robb Dear Robb:

I just saw the listing of your article on hormesis and look forward to receiving it in the very near future. As you may know, I have been researching this area for a long time. I have come to believe that hormesis will define the performance capacity of all biological systems. If you would like me to send you pdfs of my published articles on hormesis I would be pleased to do so.

Ed Calabrese

Ed-
I am absolutely familiar with your work and I’d love anything you might have the time to send. robb at norcalsc dot com

Hormesis and punctuated equilibrium are truly fascinating topics. Coach Greg Glassman has put forward the notion that crossfit is effective as a strength & conditioning program because (in his words) crossfit “Increases work capacity across broad time and modal domains”. To me this is almost an operational definition of life AND is illustrative of the need for punctuated, intense stimuli. Hormesis also explains the seeming contradiction between oxidative stress and the inability of antioxidant supplementation to improve/ameliorate disease states. really interesting stuff!
Robb

]]> By: Saul Jimenez http://www.robbwolf.com/2007/10/30/obesity-with-or-without-insulin-resistance/#comment-1170 Saul Jimenez Thu, 15 Nov 2007 05:58:45 +0000 http://robbwolf.com/?p=37#comment-1170 Robb, My Oly meet, 44th Annual Golden West Open at FIT in Los Altos, CA, went really well. I won my weight class (69 kg). After studying the video from my lifts it is clear that my technique needs some serious help, but my goal of body weight snatch and 100 kg C&J is very doable. I was able to drop weight to 68.9 kg pretty easily. I am not really sure where I started. The last time I officially weighed myself was at Masters Nationals in March and I was 74 Kg. Most of that has come off since I started The Zone near the first of August and then getting help from you around the first of September. The good news is that after a minor eating binge post-contest, I am back to right around 69 Kg with very little effort. Not only that, one of the athletes that I am training and who is following your recommendations in "42 Ways to Skin The Zone" dropped his Fran time over 2 minutes to 4:05. I could go on with other success stories but I'll stop here. Robb, thank you for all your help with getting The Zone working for me. Your help has been crucial to my success and to my clients' as well. Saul- thanks Amigo! Send some photos in when you nail the 100kg C&J. I'm glad the Zone tweaks are of benefit! Robb, My Oly meet, 44th Annual Golden West Open at FIT in Los Altos, CA, went really well. I won my weight class (69 kg). After studying the video from my lifts it is clear that my technique needs some serious help, but my goal of body weight snatch and 100 kg C&J is very doable. I was able to drop weight to 68.9 kg pretty easily. I am not really sure where I started. The last time I officially weighed myself was at Masters Nationals in March and I was 74 Kg. Most of that has come off since I started The Zone near the first of August and then getting help from you around the first of September. The good news is that after a minor eating binge post-contest, I am back to right around 69 Kg with very little effort. Not only that, one of the athletes that I am training and who is following your recommendations in “42 Ways to Skin The Zone” dropped his Fran time over 2 minutes to 4:05. I could go on with other success stories but I’ll stop here.

Robb, thank you for all your help with getting The Zone working for me. Your help has been crucial to my success and to my clients’ as well.

Saul-
thanks Amigo! Send some photos in when you nail the 100kg C&J. I’m glad the Zone tweaks are of benefit!

]]> By: Saul Jimenez http://www.robbwolf.com/2007/10/30/obesity-with-or-without-insulin-resistance/#comment-1169 Saul Jimenez Tue, 06 Nov 2007 19:48:42 +0000 http://robbwolf.com/?p=37#comment-1169 Another scenario that could cause some variance is the person that has low calorie, but high glycemic index (and possibly high stimulant i.e. soda/coffee/tobacco) diet. At least where I live, it is easy to find people who are eating poorly but still have a low BMI and have enough fitness to do relatively well on a running/aerobic test. While there is plenty of room for investigation it seems pretty clear that the "low-hanging fruit" of health is still to adopt a diet that addresses insulin sensitivity, rather than just reducing calories. If the person doesn't lose weight at least they will take themselves out of the high-risk category of overweight/obese AND insulin resistant or know for sure that they need clinical intervention. saulj Saul- You are right and not everyone with overt insulin resistance is overweight. this is the skinny-fat phenomena and it is still typified by an athrogenic blood profile and inflammatory markers. Good to see you this weekend! How did the Oly meet go? Another scenario that could cause some variance is the person that has low calorie, but high glycemic index (and possibly high stimulant i.e. soda/coffee/tobacco) diet. At least where I live, it is easy to find people who are eating poorly but still have a low BMI and have enough fitness to do relatively well on a running/aerobic test.

While there is plenty of room for investigation it seems pretty clear that the “low-hanging fruit” of health is still to adopt a diet that addresses insulin sensitivity, rather than just reducing calories. If the person doesn’t lose weight at least they will take themselves out of the high-risk category of overweight/obese AND insulin resistant or know for sure that they need clinical intervention.

saulj

Saul-
You are right and not everyone with overt insulin resistance is overweight. this is the skinny-fat phenomena and it is still typified by an athrogenic blood profile and inflammatory markers. Good to see you this weekend! How did the Oly meet go?

]]> By: Ratzo http://www.robbwolf.com/2007/10/30/obesity-with-or-without-insulin-resistance/#comment-1168 Ratzo Thu, 01 Nov 2007 20:07:56 +0000 http://robbwolf.com/?p=37#comment-1168 Robb, Not sure if you looked, but the full-text of that study is available online. It shows insulin does correlate with total fat, subcutaneous, and visceral fat, but that it only explains 50% or so of the variance. Ratzo- I did find the whole study although he allude to this in the abstract. That other 50% is certainly an interesting place of further investigation. Robb Robb,

Not sure if you looked, but the full-text of that study is available online. It shows insulin does correlate with total fat, subcutaneous, and visceral fat, but that it only explains 50% or so of the variance.
Ratzo-
I did find the whole study although he allude to this in the abstract. That other 50% is certainly an interesting place of further investigation.
Robb

]]> By: www.topweightlosssecrets.info » Obesity, With or Without Insulin Resistance? http://www.robbwolf.com/2007/10/30/obesity-with-or-without-insulin-resistance/#comment-1167 www.topweightlosssecrets.info » Obesity, With or Without Insulin Resistance? Wed, 31 Oct 2007 09:36:16 +0000 http://robbwolf.com/?p=37#comment-1167 [...] robbwolf placed an interesting blog post on Obesity, With or Without Insulin Resistance?.Here’s a brief overview:An interesting observation with these folks is that insulin resistance is obviously not a player in obesity (the folks have virtually no body fat) but it absolutely is a player in a blood lipid profile that is unhealthy and will lead to … [...] [...] robbwolf placed an interesting blog post on Obesity, With or Without Insulin Resistance?.Here’s a brief overview:An interesting observation with these folks is that insulin resistance is obviously not a player in obesity (the folks have virtually no body fat) but it absolutely is a player in a blood lipid profile that is unhealthy and will lead to … [...]

]]> By: Jeremy Shepard http://www.robbwolf.com/2007/10/30/obesity-with-or-without-insulin-resistance/#comment-1166 Jeremy Shepard Wed, 31 Oct 2007 02:37:54 +0000 http://robbwolf.com/?p=37#comment-1166 "Jeremy- If you search pubmed or Google for ketosis and leptin you will find some interesting info that looks at this." That's my fault, Robb. I misread it and assumed that you meant a KD would keep leptin elevated in the presence of weight loss. Jeremy- I think this relates to what Mary mentioned regarding Jeff Volek's research. ketosis without weight loss may not decrease leptin levels, whereas Ketosis with weight loss certainly appears to accomplish this. I'll do some more poking around on the topic. “Jeremy-
If you search pubmed or Google for ketosis and leptin you will find some interesting info that looks at this.”

That’s my fault, Robb. I misread it and assumed that you meant a KD would keep leptin elevated in the presence of weight loss.

Jeremy-
I think this relates to what Mary mentioned regarding Jeff Volek’s research. ketosis without weight loss may not decrease leptin levels, whereas Ketosis with weight loss certainly appears to accomplish this. I’ll do some more poking around on the topic.

]]> By: Sully http://www.robbwolf.com/2007/10/30/obesity-with-or-without-insulin-resistance/#comment-1165 Sully Wed, 31 Oct 2007 02:35:56 +0000 http://robbwolf.com/?p=37#comment-1165 Robb, Not completely related to the topic, but take a look at Dr. McCleary's blog over at drmccleary.com. F'ing fantastic. Sully That is a GREAT site! I need to update my links and that is going in for sure. thanks Sully! Robb Robb,

Not completely related to the topic, but take a look at Dr. McCleary’s blog over at drmccleary.com. F’ing fantastic.

Sully

That is a GREAT site! I need to update my links and that is going in for sure. thanks Sully!
Robb

]]> By: Mary http://www.robbwolf.com/2007/10/30/obesity-with-or-without-insulin-resistance/#comment-1164 Mary Wed, 31 Oct 2007 02:23:55 +0000 http://robbwolf.com/?p=37#comment-1164 Hey Robb, At the American Society of Bariatric Physician this spring in Nashville TN, Jeff Volek presented a study of low fat diets vs. very low carb ketogenic diets. Leptin levels decreased more with the low carb diet than the low fat diet indicating an increase in leptin sensitivity. If I remember correctly leptin decreased by 40% on low carb and 18% on low fat. Mary- When I did some digging on this I found most of the leptin refrences to be in both low carb AND caloric restriction (hypocaloric). The the material I referred to yesterday was for non-caloric restriction scenarios. I'll give this some thought and research and see if there is a distinction between these two situations or if I'm just full of dookey! Either way Volek and folks associated with him are doing fundamental research showing that low carb diets, whether calorie restricted or not, ameliorate the athrogenic blood profile whereas low fat diets DO NOT. Here is a great resource for much of this work: http://www.nutritionandmetabolism.com/content/3/1/24 Thanks Marry! Robb Hey Robb,

At the American Society of Bariatric Physician this spring in Nashville TN, Jeff Volek presented a study of low fat diets vs. very low carb ketogenic diets. Leptin levels decreased more with the low carb diet than the low fat diet indicating an increase in leptin sensitivity. If I remember correctly leptin decreased by 40% on low carb and 18% on low fat.

Mary-
When I did some digging on this I found most of the leptin refrences to be in both low carb AND caloric restriction (hypocaloric). The the material I referred to yesterday was for non-caloric restriction scenarios. I’ll give this some thought and research and see if there is a distinction between these two situations or if I’m just full of dookey! Either way Volek and folks associated with him are doing fundamental research showing that low carb diets, whether calorie restricted or not, ameliorate the athrogenic blood profile whereas low fat diets DO NOT. Here is a great resource for much of this work:
http://www.nutritionandmetabolism.com/content/3/1/24
Thanks Marry!
Robb

]]> By: Healthy Diet » Obesity, With or Without Insulin Resistance? http://www.robbwolf.com/2007/10/30/obesity-with-or-without-insulin-resistance/#comment-1163 Healthy Diet » Obesity, With or Without Insulin Resistance? Tue, 30 Oct 2007 22:57:11 +0000 http://robbwolf.com/?p=37#comment-1163 [...] Robb Wolf wrote an interesting post today on Obesity, With or Without Insulin Resistance?Here’s a quick excerpt I wanted to thank Ratzo for a great question and also for tracking down a citation for further … more than six-fold in an apparently healthy population, and approximately one third of the most [...] [...] Robb Wolf wrote an interesting post today on Obesity, With or Without Insulin Resistance?Here’s a quick excerpt I wanted to thank Ratzo for a great question and also for tracking down a citation for further … more than six-fold in an apparently healthy population, and approximately one third of the most [...]

]]> By: Diet Foods » Blog Archive » Obesity, With or Without Insulin Resistance? http://www.robbwolf.com/2007/10/30/obesity-with-or-without-insulin-resistance/#comment-1162 Diet Foods » Blog Archive » Obesity, With or Without Insulin Resistance? Tue, 30 Oct 2007 21:38:04 +0000 http://robbwolf.com/?p=37#comment-1162 [...] Robb Wolf wrote an interesting post today on Obesity, With or Without Insulin Resistance?Here’s a quick excerpt I wanted to thank Ratzo for a great question and also for tracking down a citation for further discussion. Here is the original question: Hi Robb,I posted this question on Art Devany’s site, since I am very curious about it.If insulin is the key to body composition, then how are there people in studies who are insulin sensitive yet who are [...] [...] Robb Wolf wrote an interesting post today on Obesity, With or Without Insulin Resistance?Here’s a quick excerpt I wanted to thank Ratzo for a great question and also for tracking down a citation for further discussion. Here is the original question: Hi Robb,I posted this question on Art Devany’s site, since I am very curious about it.If insulin is the key to body composition, then how are there people in studies who are insulin sensitive yet who are [...]

]]> By: Jeremy Shepard http://www.robbwolf.com/2007/10/30/obesity-with-or-without-insulin-resistance/#comment-1161 Jeremy Shepard Tue, 30 Oct 2007 20:57:09 +0000 http://robbwolf.com/?p=37#comment-1161 "Interestingly a ketogenic diet does not lower leptin levels yet it does emulate other elements of fasting." Robb, can you elaborate on the reasoning for this statement or post a reference? Jeremy- If you search pubmed or Google for ketosis and leptin you will find some interesting info that looks at this. The statement regarding ketosis and fasting comes from much of the research I've put into intermittent fasting, hormesis the ketosis and cancer post. If folks are seriously interested in this I can tie that together but it's rehashing a lot of material I have written on previously. “Interestingly a ketogenic diet does not lower leptin levels yet it does emulate other elements of fasting.”

Robb, can you elaborate on the reasoning for this statement or post a reference?

Jeremy-
If you search pubmed or Google for ketosis and leptin you will find some interesting info that looks at this. The statement regarding ketosis and fasting comes from much of the research I’ve put into intermittent fasting, hormesis the ketosis and cancer post. If folks are seriously interested in this I can tie that together but it’s rehashing a lot of material I have written on previously.

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